Ricerc@Sapienza

Malassezia species are natural inhabitants of the healthy skin. However, under certain
conditions, they may cause or exacerbate several skin diseases. The ability of this fungus
to colonize or infect is determined by complex interactions between the fungal cell and
its virulence factors. This study aims to evaluate “in vitro” the hydrophobicity levels,
the adherence on a plastic surface and the biofilm formation of 16 clinical isolates of
Malassezia furfur. Cellular surface hydrophobicity (CSH) levels were determined by twophase

Several human skin diseases are associated with fungi as dermatophytes and Malassezia. Skin mycoses are increasing and new alternatives to conventional treatments with improved efficacy and/or safety profiles are desirable. For the first time, the anti-dermatophytes and the anti-Malassezia activities of Vitis vinifera seed extracts obtained from different table and wine cultivars have been evaluated. Geometric minimal inhibitory concentration ranged from 20 to 97?µg/mL for dermatophytes and from 32 to 161?µg/mL for Malassezia furfur.