Ricerc@Sapienza

The fragmentation of the isolated 5-bromouracil (5BrU) molecule and pure and nano-hydrated 5BrU clusters induced by low energy 12C4+ ions has been studied. A comparison indicates that the environment, on the one hand, protects the system against the complete break-up into small fragments, but, on the other hand, triggers 'new' pathways for fragmentation, for example the loss of the OH group. The most striking result is the observation of several series of hydrated fragments in the hydrated cluster case, with water molecules bound to hydrophilic sites of 5BrU.

High-grade gliomas(HGGs) in pediatric age have the same bad prognosis as those arising in adults. Approximately one-half of HGGs in children
occur in the brain stem, most frequently within the pons as diffuse intrinsic pontine glioma or other midline structures. Although they have the
same histological appearance of adult malignant gliomas, in recent years, the extensive use of molecular profiling techniques has demonstrated
significant molecular differences between the two age groups. These data have led to a major reclassification of pediatric HGG (pHGG) based