Ricerc@Sapienza

Nowadays, the multidisciplinary team (MDT) is an essential component for oncologic disease management. Its benefit is also extensively recognized in head and neck cancer (HNC) community, due to tumor rarity and complex treatment. A well-defined MDT management serves as a stable point to define the better strategy and offers a chance to optimize HNC clinical outcomes and patient's quality of life. We explored both mandatory and additional requirements for establishing a high-quality MDT. Then we proposed an example of HNC MDT organization.

Neuromyelitis optica (NMO) and Neuromyelitis optica spectrum disorders (NMOSD) are a group of autoimmune conditions characterized by inflammatory involvement of the optic nerve, spinal cord and central nervous system. Novel evidence showed a key role of autoantibodies against aquaporin-4 immunoglobulin G (AQP4 IgG) in the pathogenesis of NMOSD and, recently, new classification and diagnostic criteria have been adopted to facilitate an earlier identification and improve the management of these conditions.

Introduction: Neuromyelitis optica spectrum disorders (NMOSD) are autoimmune diseases of the central nervous system mainly involving the optic nerves and spinal cord. Many advances have been made in understanding the immunopathology of NMOSD and related clinical classification, nevertheless, open issues in management and effective therapeutic approaches still remain.

Purpose: Multidisciplinary approach is widely advised for an effective care of patients with neuroendocrine neoplasia (NEN). Since data on efficacy of multidisciplinary management of NENs patients in referral centers are scanty, this study aimed at analyzing the modality of presentation and clinical outcome of patients with NENs managed by a dedicated multidisciplinary team. Methods. In this prospective observational study, we included all consecutive new patients visiting the Sant'Andrea Hospital in Rome (ENETS-Center of Excellence) between January 2014 and June 2018. Results.

Background: Although diverticular disease is a common condition, its effective treatment is challenging in clinical practice.
Objective: The objective of this article is to assess pharmacological management in different clinical settings of diverticular
disease and factors associated with treatment using the Italian registry Registro Malattia Diverticolare (REMAD).
Methods: At study enrolment, patients were categorised into subgroups: diverticulosis, symptomatic uncomplicated diverticular

A network of endometriosis experts from 16 Italian academic departments and teaching hospitals distributed all over the country made a critical appraisal of the available evidence and definition of 10 suggestions regarding measures to be de-implemented. Strong suggestions were made only when high-quality evidence was available. The aim was to select 10 low-value medical interventions, characterized by an unfavorable balance between potential benefits, potential harms, and costs, which should be discouraged in women with endometriosis.

The incidence of endometriosis in middle-aged women is not minimal compared to that in the reproductive age group. The treatment of affected women after childbearing age to the natural transition toward menopause has received considerably poor attention. Disease management is problematic for these women due to increased contraindications regarding hormonal treatment and the possibility for malignant transformation, considering the increased cancer risk in patients with a long-standing history of the disease.

In order to improve power system operation, Battery Energy Storage Systems (BESSs) have been installed in high voltage/medium voltage stations by Distribution System Operators (DSOs) around the world. Support for restoration of MV distribution networks after a blackout or HV interruption is among the possible new functionalities of BESSs. With the aim to improve quality of service, the present paper investigates whether a BESS, installed in the HV/MV substation, can improve the restoration process indicators of a distribution grid.

The present study investigates an oil spill event in the Al Khafji region using Sentinel 1 SAR images. Al Khafji is on the border between Saudi Arabia and Kuwait in the Persian Gulf and it is considered a neutral zone. Al Khafji region has the potential to produce more than 470,000 barrels of oil per day (Mbbl/d). Methods based on multi sensor satellite images (Sentinel-2, Landsat 8, Terra, Cosmo_SkyMed, RADARSAT, etc.) analysis have been developed for detecting oil slicks from known natural seeps as well as oil spill events.

In this study, the measured wave data for year 2010 at 3 hour time step for six sites in the Caspian sea, Persian Gulf and Oman Sea of Iran have been statistically analysed to determine the wave power potential of Iranian coastlines. The statistical attitudes allows to estimate the significant weight height (Hs), peak wave energy period (Tp), and the wave energy flux for unit of crest length.