Use of organoids in medicinal chemistry: challenges on ethics and biosecurity
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medicinal chemistry
Sirtuins as drug targets
The mammalian sirtuins (SIRTs) are evolutionally highly conserved proteins
and belong to class III histone deacetylases (HDACs). Its seven family members
(SIRT1–7) share a NAD+-dependent catalytic protein lysine deacetylase and/or
mono-ADP-ribosylase mechanism and are involved in various biological
processes acting on diverse substrates. SIRTs vary in length and sequence at
their N- and C-termini. This might explain in part their diverse functions and
localizations. To date, their protein lysine deacetylation is the most studied
Teaching and learning computational drug design: student investigations of 3D quantitative structure–activity relationships through web applications
The increasing use of information technology in the discovery of new molecular entities encourages the use of modern molecular-modeling tools to help teach important concepts of drug design to chemistry and pharmacy undergraduate students. In particular, statistical models such as quantitative structure activity relationships (QSAR)—often as its 3-D QSAR variant—are commonly used in the development and optimization of a leading compound.