memory extinction

Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD)

Post-Traumatic Stress Disorder (PTSD) is a psychiatric disorder whose pathogenesis relies on a maladaptive expression of the memory for a life-threatening experience, characterized by over-consolidation, generalization and impaired extinction, which are responsible of dramatic changes in arousal, mood, anxiety and social behavior. Even if subjects experiencing a traumatic event during lifetime all show an acute response to the trauma, only a subset of them (susceptible) ultimately develops PTSD, meanwhile the others (resilient) fully recover after the first acute response.

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