Ricerc@Sapienza

The identification of microRNAs in biological fluids for diagnosis and prognosis is receiving great attention in the field of multiple sclerosis (MS) research but it is still in its infancy. In the present study, we observed in a large sample of MS patients that let-7b-5p levels in the cerebrospinal fluid (CSF) were highly correlated with a number of microRNAs implicated in MS, as well as with a variety of inflammation-related protein factors, showing specific expression patterns coherent with let-7b-5p-mediated regulation.

A relevant challenge for the improvement of clear cell renal cell carcinoma management could derive from the
identification of novel molecular biomarkers that could greatly improve the diagnosis, prognosis, and treatment choice of these neoplasms. In
this study, we investigate whether quantitative parameters obtained from computed tomography texture analysis (CTTA) may correlate with the
expression of selected oncogenic microRNAs (miRNA). To the best of our knowledge, a possible correlation between CT texture parameters and