Relation of redox and structural alterations of rat skin in the function of chronological aging
Accumulation of oxidative insults on molecular and supramolecular levels could compromise renewal potency and architecture in the aging skin.
mitochondrion
P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation
The epigenetic enzyme p300/CBP-associated factor (PCAF) belongs to the GCN5-related N-acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post-translational function is well characterized, little is known about its properties as regulator of cell metabolism. Here, we report the mitochondrial localization of PCAF conferred by an 85 aa mitochondrial targeting sequence (MTS) at the N-terminal region of the protein. In mitochondria, one of the PCAF targets is the isocitrate dehydrogenase 2 (IDH2) acetylated at lysine 180.