Ricerc@Sapienza

Nonalcoholic fatty liver disease (NAFLD) is considered to be the most common chronic liver disease. The discovery of natural product-based NAFLD modulators requires a more comprehensive study of their modes of action (MoAs). In this study we analysed available in the literature data for 26 naturally-derived compounds associated with experimental evidence for NAFLD alleviation and outlined potential biomolecular targets and a network of pharmacological MoAs for 12 compounds with the highest number of experimentally supported MoA key events, modulated by them.

The cell division cycle 25 phosphatases (CDC25A, B, and C; E.C. 3.1.3.48) are key regulator of the cell cycle in human cells. Their aberrant expression has been associated with the insurgence and development of various types of cancer, and with a poor clinical prognosis. Therefore, CDC25 phosphatases are a valuable target for the development of small molecule inhibitors of therapeutic relevance. Here, we used an integrated strategy mixing organic chemistry with biological investigation and molecular modeling to study novel quinonoid derivatives as CDC25 inhibitors.

1. Scientists have repeatedly argued that transformative, multiscale global scenarios
are needed as tools in the quest to halt the decline of biodiversity and achieve
sustainability goals.
2. As a first step towards achieving this, the researchers who participated in the
scenarios and models expert group of the Intergovernmental Science-Policy
Platform on Biodiversity and Ecosystem Services (IPBES) entered into an iterative,
participatory process that led to the development of the Nature Futures Framework
(NFF).

Predicting how species respond to human pressure is essential to anticipate their decline and identify appropriate conservation strategies. Both human pressure and extinction risk change over time, but their inter-relationship is rarely considered in extinction risk modelling. Here we measure the relationship between the change in terrestrial human footprint (HFP)-representing cumulative human pressure on the environment-and the change in extinction risk of the world's terrestrial mammals.

Mass migration to Europe from countries in a state of war is one of the most important emerging phenomenon which has to be interpreted in the future of architecture and urbanism and as a new element to be included in new models beng defined that govern the urban transformation of contemporary cities.

Mass migration to Europe from countries in a state of war is one of the most important emerging phenomenon which has to be interpreted in the future of architecture and urbanism and as a new element to be included in new models beng defined that govern the urban transformation of contemporary cities.

Cloud Computing is the new technology that is changing our practices and attitudes. How should archivists arrange and describe resources in such environment? More specifically, how is the cloud environment going to affect arrangement and description theory and practice? What is the impact of preserving and providing access to archives in the cloudm in light of the traditional principles of provenance, respect des fonds and original order?What is the role of traditional finding aids , if any, in describing cloud-based fesources?

Tinnitus is a debilitating perception of sound in the absence of external auditory stimuli. It may have either a central or a peripheral origin in the cochlea. Experimental studies evidenced that an electrical stimulation of peripheral auditory fibers may alleviate symptoms but the underlying mechanisms are still unknown. In this work, a stochastic neuron model is used, that mimics an auditory fiber affected by tinnitus, to check the effects, in terms of firing reduction, of different kinds of electric stimulations, i.e., continuous wave signals and white Gaussian noise.

Blood-feeding animals are known for their ability to produce bioactive compounds to impair haemostasis and suppress pain perception in the host. These compounds are extremely appealing for pharmacological development since they are generally very effective and specific for their molecular target. A preliminary RNA-Seq based characterization of the secretion from salivary and mid-oesophageal tissues of the vampire snail Cumia reticulata, revealed a complex mixture of feeding-related transcripts with potential anaesthetic and anticoagulant action.

Methiopropamine (MPA) is a structural analogue of methamphetamine and belongs to the category of the novel psychoactive substances. To the best of our knowledge, no experimental study has been performed to evaluate the organ damage evoked by MPA administration in an animal model. Therefore, the main purpose of the present study was to investigate the histological changes in CD-1 male mice following the chronic administration of MPA.