Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study
Rhinovirus (RV)?, member of the Enterovirus genus, is known to be involved in more than half of the common colds. Through advances in mol. biol., rhinoviruses have also been assocd. with exacerbations of chronic pulmonary diseases (e.g., asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis)?. In the current investigation, the authors develop a novel series of 4,?5-?dimethoxybenzyl derivs. that potently inhibits rhinovirus replication. Compd.