Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS
Long non-coding RNAs (lncRNAs) are currently recognized as crucial players in nervous system development,
function and pathology. In Amyotrophic Lateral Sclerosis (ALS), identification of causative mutations in FUS
and TDP-43 or hexanucleotide repeat expansion in C9ORF72 point to the essential role of aberrant RNA metabolism
in neurodegeneration. In this study, by taking advantage of an in vitro differentiation system generating
mouse motor neurons (MNs) from embryonic stem cells, we identified and characterized the long non-coding