Ricerc@Sapienza

Both tissue repair and regeneration are a priority in regenerative medicine. Retinitis
pigmentosa (RP), a complex retinal disease characterized by the progressive loss of impaired
photoreceptors, is currently lacking effective therapies: this represents one of the greatest challenges in
the field of ophthalmological research. Although this inherited retinal dystrophy is still an incurable
genetic disease, the oxidative damage is an important pathogenetic element that may represent a

Spectrometric and analytical techniques in general collect multivariate signals from chemical or biological materials by means of a specific measurement instrumentation, usually in order to characterize or classify them through the estimation of one of several compounds of interest. However, measurement conditions might induce various additive (baseline) or multiplicative effects on the collected signals, which may jeopardize the accuracy and generalizability of estimation models.