Multivariate analysis

Crisis-driven changes in construction patterns: evidence from building permits in a Mediterranean city

This study aimed to describe the construction sector’s response to the 2007–2008 recession based on the spatial analysis of 10 building activity indicators over a 25-year period (1990–2014) in Athens, Greece. Expansion and recession cycles influenced the average values of four indicators (density of new buildings, average floors per new building, density of enlarged buildings and building permits per inhabitant) without altering their spatial pattern.

Tooth extraction without discontinuation of oral antithrombotic treatment: a prospective study

To identify which variable, among those related to surgeries, to patients, or to antithrombotic treatments, could be considered as a bleeding indicator, and to analyze effectiveness of the local hemostatic protocols used, incidence of bleeding and healing index, depending on the number of extracted teeth, and patient antithrombotic treatment.

To what extent are surgeons capable of establishing the difficulty degree of lower third molar surgery pre-operatively?

Background: Several methods and variables have been proposed to evaluate surgical difficulty in lower third molar extraction. Aims: The main aim of the present study is to identify which variable influences most the surgeon’s judgment on technical difficulty and which patient- and tooth-related variables are directly associated with an increase in surgical difficulty. Materials & Methods: A prospective observational study was performed.

Activation of C-H bonds by a nonheme iron(iv)-oxo complex: Mechanistic evidence through a coupled EDXAS/UV-Vis multivariate analysis

The understanding of reactive processes involving organic substrates is crucial to chemical knowledge and requires multidisciplinary efforts for its advancement. Herein, we apply a combined multivariate, statistical and theoretical analysis of coupled time-resolved X-ray absorption (XAS)/UV-Vis data to obtain detailed mechanistic information for on the C-H bond activation of 9,10-dihydroanthracene (DHA) and diphenylmethane (Ph2CH2) by the nonheme FeIV-oxo complex [N4Py·FeIV(O)]2+ (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) in CH3CN at room temperature.

Direct structural and mechanistic insights into fast bimolecular chemical reactions in solution through a coupled XAS/UV-Vis multivariate statistical analysis

In this work, we obtain detailed mechanistic and structural information on bimolecular chemical reactions occurring in solution on the second to millisecond time scales through the combination of a statistical, multivariate and theoretical analysis of time-resolved coupled X-ray Absorption Spectroscopy (XAS) and UV-Vis data. We apply this innovative method to investigate the sulfoxidation of p-cyanothioanisole and p-methoxythioanisole by the nonheme FeIV oxo complex [N4Py·FeIV(O)]2+ (N4Py = N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) in acetonitrile at room temperature.

The “BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons” (BIOSPHERE) study: rationale, design and methods

Sarcopenia, the progressive and generalised loss of muscle mass and strength/function, is a major health issue in older adults given its high prevalence and burdensome clinical implications. Over the years, this condition has been endorsed as a marker for discriminating biological from chronological age. However, the absence of a unified operational definition has hampered its full appreciation by healthcare providers, researchers and policy-makers.

Biomarkers for sarcopenia: reductionism vs. complexity

Sarcopenia, the progressive and generalized loss of muscle mass and strength/function, is a major health issue in older adults, given its high prevalence and burdensome clinical ramifications. The absence of a unified operational definition for sarcopenia has hampered its full appreciation by healthcare providers, researchers and policy-makers. At the same time, this unresolved debate and the complexity of musculoskeletal aging pose major challenges to the identification of clinically meaningful biomarkers.

Circulating amino acid signature in older people with Parkinson's disease: a metabolic complement to the EXosomes in PArkiNson Disease (EXPAND) study

Background and aim: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in old age. Neurotoxicity of dopaminergic neurons triggered by aggregation of misfolded α-synuclein is a major pathogenic trait of PD. However, growing evidence indicates that peripheral processes, including metabolic changes, may precede and contribute to neurodegeneration. The present study was undertaken to identify a metabolic signature of PD through the quantification of serum amino acids and derivatives.

Multivariate statistics: considerations and confidences in food authenticity problems

Modern analytical measurement technologies, such as infrared, NMR, mass spectrometry and chromatography, provide a wealth of information on the chemical composition of all kinds of samples. These instruments are invariably controlled by computers, and the data (spectrum, chromatogram) recorded in digital form. A measurement on a single sample typically comprises thousands of numbers. Usually, this is many more than the number of samples, meaning that the experiment overall is underdetermined.

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