Epigenetic Regulation of Muscle Stem Cells During Skeletal Muscle Regeneration and Disease
Skeletal muscle possesses a remarkable capacity to regenerate upon injury thanks to the presence of a population of stem cells called muscle satellite cells (MuSCs). These cells, normally quiescent in resting conditions, become activated by extracellular cues released in the regenerative environment, expand and then differentiate into mature myofibers to properly repair injured muscles. During regenerative cycles, MuSCs undergo dramatic epigenetic changes that dictate activation or repression of specific transcriptional programs needed to transit along different cell fates.