During the infectious process Mycobacterium tuberculosis typically encounters an acid stress in the human macrophage phago(lyso)some (pH 4.5-6.0) [1]. Nonetheless, how M. tuberculosis survives this challenge is little understood.
Epigenetics regulate gene function without any alteration in the DNA sequence. The epigenetics represent one of the most important regulators in different cellular processes and have initially been developed in microorganisms as a protective strategy. The evaluation of the epigenetic mechanisms is also important in achieving an efficient control strategy in tuberculosis (TB). TB is one of the most significant epidemiological concerns in human history.
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