Ricerc@Sapienza

The aim of this work was to investigate on the possibility to use nano-magnetite particles supported on waste biomass as heterogeneous catalyst for the production of p-aminophenol starting from a well-known pollutant, p-nitrophenol, in fixed-bed reactors. The kinetic and the thermodynamic of the process was firstly studied in batch system, subsequently a first scale-up was performed using a glass column packed with the supported catalyst. The experimental data obtained with the column were interpreted in light of a suitable dynamic model.

Cationic antimicrobial peptides (AMPs) are an interesting class of gene-encoded molecules endowed with a broad-spectrum of anti-infective activity and immunomodulatory properties. They represent promising candidates for the development of new antibiotics, mainly due to their membrane-perturbing mechanism of action that very rarely induces microbial resistance. However, bringing AMPs into clinical field is hampered by some intrinsic limitations, encompassing low peptide bioavailability at the target site and high peptide susceptibility to proteolytic degradation.

In recent years, novel nanofabrication approaches have attracted the growing interest of researchers in the biomedical field. Nanomaterials are highly versatile tools that can interact with cells in general, including bacteria, animal and plant cells. When used as drug carriers, NPs can afford improved circulation and biodistribution, in addition to high drug loading and controlled release rates, as well as protection from degradation that may occur both in vitro and in vivo.

The protein corona (PC) that forms around nanomaterials upon exposure to human biofluids (e.g., serum, plasma, cerebral spinal fluid etc.) is personalized, i.e., it depends on alterations of the human proteome as those occurring in several cancer types. This may relevant for early cancer detection when changes in concentration of typical biomarkers are often too low to be detected by blood tests.