Reconstitution of multifunctional CD56(low)CD16(low) natural killer cell subset in children with acute leukemia given ?/? T cell-depleted HLA-haploidentical haematopoietic stem cell transplantation
We recently described the CD56lowCD16low subset of Natural Killer (NK) cells that both mediate cytotoxic activity and produce IFN?, being more abundant in bone marrow (BM) than in peripheral blood (PB) of pediatric normal subjects. Given the multifunctional properties of this subset, we examined its development and functional recovery in a cohort of children undergoing ?/? T-cell depleted HLA-haploidentical haematopoietic stem cell transplantation (HSCT).