Ricerc@Sapienza

Background/Aim: Endoscopic vacuum-assisted closure therapy (EVAC) is a promisingnew technique for repairing upper gastrointestinal defects of different etiologies. As of 2018, however, no standardized recommendation exists. This articlereviewed EVAC in treating anastomotic leakagefollowing major resective surgery of esophageal (EC) and gastric cancer(GC).Materials and Methods: Only English-language literature was investigated. Only studies or data on EC and GC were included.

Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains aclosed, humid, sterile and isolated environment. Wound infection is considered arelative contraindication. The objective of this study is to extend the indications forVAC therapy to include infected wounds by demonstrating its ability to increase theantibiotic concentration in the damaged and infected tissues. Patients who presentedwith ulcers infected with daptomycin-sensitive bacteria were eligible to be enrolledin this prospective study.