Background: The purpose of this review is to provide a comprehensive overview of the findings of clinical electrophysiology studies aimed to investigate changes in information processing of migraine with aura patients. Main body: Abnormalities in alpha rhythm power and symmetry, the presence of slowing, and increased information flow in a wide range of frequency bands often characterize the spontaneous EEG activity of MA.
RESULTS: The intent-to-treat population consisted of 243 patients. The nVNS group (n = 120) had a significantly greater percentage of attacks treated during the double-blind period that were pain-free at 60 (P = 0.005) and 120 min (P = 0.026) than the sham group (n = 123) did. Similar results were seen for attacks with pain relief at 60 (P = 0.025) and 120 min (P = 0.018).
Background: The PRESTO study of non-invasive vagus nerve stimulation (nVNS; gammaCore®) featured key primary and secondary end points recommended by the International Headache Society to provide Class I evidence that for patients with an episodic migraine, nVNS significantly increases the probability of having mild pain or being pain-free 2 h post stimulation.
In this chapter, we review the findings obtained by neurophysiological studies in migraine with aura (MA).
Spontaneous electroencephalography activity in MA is characterized by abnormalities in alpha rhythm power and symmetry, and the presence of slowing, and increased, information flow in a wide range of frequency bands. Evoked potential (EP) studies indicate the occurrence of increased grand-average cortical response amplitudes, interhemispheric response asymmetry, as well as deficient habituation to any kind of repetitive sensory stimulation, in MA patients.
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