Neuronal differentiation | Ricerc@Sapienza

Cellular and molecular mechanisms mediated by recPrP C involved in the neuronal differentiation process of mesenchymal stem cells

Human Dental Pulp Stem Cells (hDPSCs) represent a type of adult mesenchymal stem cells that have the ability to differentiate in vitro in several lineages such as odontoblasts, osteoblasts, chondrocytes, adipocytes and neurons. In the current work, we used hDPSCs as the experimental model to study the role of recombinant prion protein 23–231 (recPrP C ) in the neuronal differentiation process, and in the signal pathway activation of ERK 1/2 and Akt.

Rapamycin promotes differentiation increasing ?III-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells

Egr1 maintains NSC proliferation and its overexpression counteracts cell cycle exit triggered by the withdrawal of Epidermal Growth Factor

In adult mammals, neural stem cells (NSCs) reside in specialized niches at the level of selected CNS regions, such as the subventricular zone (SVZ). The signalling pathways that regulate NSCs proliferation and differentiation remain poorly understood. The early growth response gene 1 (Egr-1) is an important transcription factor, widely studied in the adult mammalian brain, mediating the activation of target genes by a variety of extracellular stimuli.