Overexpression of the vitronectin v10 subunit in patients with nonalcoholic steatohepatitis: Implications for noninvasive diagnosis of NASH
Nonalcoholic steatohepatitis (NASH) is the critical stage of nonalcoholic fatty liver disease
(NAFLD). The persistence of necroinflammatory lesions and fibrogenesis in NASH is the leading cause
of liver cirrhosis and, ultimately, hepatocellular carcinoma. To date, the histological examination of
liver biopsies, albeit invasive, remains the means to distinguish NASH from simple steatosis (NAFL).
Therefore, a noninvasive diagnosis by serum biomarkers is eagerly needed. Here, by a proteomic