Ricerc@Sapienza

Background/Aim: Endoscopic vacuum-assisted closure therapy (EVAC) is a promisingnew technique for repairing upper gastrointestinal defects of different etiologies. As of 2018, however, no standardized recommendation exists. This articlereviewed EVAC in treating anastomotic leakagefollowing major resective surgery of esophageal (EC) and gastric cancer(GC).Materials and Methods: Only English-language literature was investigated. Only studies or data on EC and GC were included.

When diabetes mellitus is not properly controlled with drugs and a healthy lifestyle, it exposes patients with advanced peripheral arterial disease or critical limb ischaemia (CLI) to the most serious complications, in particular lower limb ulcers. Surgical or endovascular treatments represent the first line of intervention; in addition, the adequate management of ulcers can guarantee not only a faster wound healing but also the improvement of the patient's prognosis.

An altered balance between metalloproteinases (MMPs) and their inhibitor tissue inhibitor of metalloproteinases (TIMPs) may influence the healing process of a minor amputation following a successful vein graft. To speed up this process, negative pressure wound therapy (NPWT) and advanced moist wound dressing have been proposed.