Ricerc@Sapienza

The investigation on neurotransmission function during normal and pathologic development is a pivotal component needed to understand the basic mechanisms underlying neurodevelopmental pathologies. To study these diseases, many animal models have been generated which allowed to face the limited availability of human tissues and, as a consequence, most of the electrophysiology has been performed on these models of diseases.

Erythropoietin (EPO)is a hematopoietic growth factor that has an important role in the erythropoiesis. EPO and its receptor (EPO-R)are expressed all over in the mammalian brain. Furthermore, it has been reported that EPO may exert neuroprotective effect in animal models of brain disorders as ischemia and epilepsy. Here, we investigate whether EPO could modulate the GABA-evoked currents (I GABA )in both human epileptic and non-epileptic control brain tissues.