Ricerc@Sapienza

A 42-year-old woman presented to our hospital owing to a history of right-sided proptosis of 4 months duration, reporting no previous trauma, fever, or recent sinusitis. Her medical record included a diagnosis of Graves’ disease. The best corrected visual acuity (BCVA) was 20/20 and a 30.2 visual field test was normal. A 3-Tesla magnetic resonance imaging (MRI) revealed an orbital apex meningioma approaching the walls of the sulcus chiasmaticus. A subsequent 60.4 perimetry test showed bilateral nasal visual field defects, thus confirming the involvement of the optic nerve.

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically characterised by cognitive deficits that gradually worsen over time. There is, at present, no established cure, or disease-modifying treatments for AD. As life expectancy increases globally, the number of individuals suffering from the disease is projected to increase substantially. Cumulative evidence indicates that AD neuropathological process is initiated several years, if not decades, before clinical signs are evident in patients, and diagnosis made.