palladium
Palladium-Catalyzed Cascade Approach to 12-(Aryl)indolo[1,2- c ]quinÂazolin-6(5 H )-ones
A straightforward one-pot approach to the synthesis of challenging 12-arylindolo[1,2-c]quinazolin-6(5H)-ones is described. Starting from readily available o-(o-aminophenylethynyl)trifluoroacetanilides, palladium-catalyzed aminoarylation of the triple bond with ArI, ArBr, and ArN2 +BF4 – is followed by cyclization of the resulting N-trifluoroacetyl-2-(o-aminophenyl)-3-aryl indole. This sequential reaction provides the title compounds by means of a rare elimination of trifluoromethane.
Palladium-catalyzed C12-selective direct arylation of [1,2-c] quinazolin-6(5H)-ones
A straightforward approach to the synthesis of challenging 12-arylindolo[1,2-c]quinazolin-6(5H)-ones through the palladium-catalyzed direct arylation of N-benzyl and NH-free[1,2-c]quinazolin-6(5H)-ones with aryl bromides and chlorides is described.