Insights into the role of innate immunity in cervicovaginal papillomavirus infection from studies using gene deficient mice
We demonstrate that female C57BL/6J mice are susceptible to a transient lower genital tract infection with MmuPV1 mouse papillomavirus and display focal histopathological abnormalities resembling human papillomavirus infection. We took advantage of strains of genetically deficient mice to study in vivo the role of innate immune signaling in control of papillomavirus. At 4 months, we sacrificed MmuPV1-infected mice and measured viral 757/3139 spliced transcripts by TaqMan RT-PCR, localization of infection by RNAscope in situ hybridization, and histopathological abnormities by H&E stain.