PERK
IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy
Sensors of endoplasmic reticulum (ER) stress function in a co-ordinated manner. In the present study we investigated
the relationship between IRE1α and PERK pathways and survival of ER stressed U937 cells and BC3 cells. To this end,
we investigated the effects of a subcytotoxic concentration of Tunicamycin in IRE1α-proficient and in IRE1α-deficient
cells, by pharmacological inhibition with 4μ8 C or down-regulation by specific siRNA. We show that either type of