Ricerc@Sapienza

BACKGROUND:Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers. AIM:To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC.

Background: Autoimmune atrophic gastritis (AAG) leads to iron and/or vitamin B12 malabsorption, with subsequent haematological alterations which could represent the sole clinical manifestation. We aimed to assess patterns of anaemia and micronutrient deficiencies in patients with AAG at the time of diagnosis. Methods: Observational, multicentre, cross-sectional study including consecutive adult patients diagnosed with AAG within the last ten years. Cell blood count, red cell distribution width, serum vitamin B12, and ferritin were collected.

Background: Autoimmune atrophic gastritis (AAG) diagnosis is based on specific histological findings and anti-parietal cell antibodies (PCA) considered the serological hallmark of AAG, although a subgroup of AAG patients may be seronegative. Objectives: to assess the occurrence and clinical features of seronegative compared to seropositive AAG. Methods: this is a cross-sectional study including 516 consecutive adult patients (age 59.6±12.8 years, F:M=2.2:1) with histologically proven AAG diagnosed in two Italian academic referral centers over the last 10 years.

Background: Atrophic gastritis (AG) is at increased risk of gastric neoplasia, thus surveillance gastroscopy
has been proposed.
Aims: To assess cost of detecting gastric neoplasias by surveillance endoscopy according to identified risk
factors in Italy.
Methods: Post-hoc analysis of a cohort study including 200 AG-patients from Italy followed up for a mean
of 7.5 (4–23.4) years was done. Considered risk factors were: age >50 years, extensive atrophy, pernicious