HLA-DQB1∗0201 phenotype and severe primary RhD immunization
Purpose of Investigation: Although post-delivery administration of anti-D immunoglobulin (anti-D Ig) and antenatal prophylaxis the residual prevalence of RH alloimmunization is due to an incomplete application of the guidelines or to clinical conditions that foster mechanisms of immunization. Materials and Methods: The authors report a case of devastating RhD alloimmunization in a secundipara, group 0 Rh negative, without potentially immunizing events. Results: Anti-D antibodies were screened at 6/2 and at 13/4 weeks and were found negative.