Phosphodiesterase 5

Molecular & Metabolic Endocrinology

Molecular & Metabolic Endocrinology

We are exploring new players involved in the interplay between metabolism and intracrinology. Using a mixed basic and translational approach, we are fascinated by how the complexity of phosphodiesterases and intracellular hormonal metabolism can shape adipocytes, endothelial cells, smooth muscle cells, stem cells, and cancer cells response to challenges.

Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5

Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP. The great clinical success of the PDE5 inhibitors, Sildenafil (Viagra), Vardenafil (Levitra) and Tadalafil (Cialis) has led to an increasing interest for this class of enzymes. Recent studies have shown a correlation between tumor growth and PDE5 overexpression, making PDE5-selective inhibitors promising candidates for cancer treatment. The search for such inhibitors rests today on radioactive assays.

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