Short-lived intermediates (encounter complexes) in cisplatin ligand exchange elucidated by infrared ion spectroscopy
Cisplatin (cis-diamminedichloroplatinum(II), cis-[PtCl2(NH3)2]), widely used drug in cancer treatment,
has been allowed to react with simple molecular targets (L) mimicking biological functional groups.
The selected molecules (L = acetamide, dimethylacetamide, urea and thiourea) react by ligand exchange
leading to cis-[PtCl(NH3)2(L)]+ complexes that have been assayed by ESI-MS, IRMPD spectroscopy and