A flow-leak correction algorithm for pneumotachographic work-of-breathing measurement during high-flow nasal cannula oxygen therapy
Measuring work of breathing (WOB) is an intricate task during high-flow nasal cannula (HFNC) ther-
apy because the continuous unidirectional flow toward the patient makes pneumotachography technically
difficult to use. We implemented a new method for measuring WOB based on a differential pneumota-
chography (DP) system, equipped with one pneumotachograph inserted in the HFNC circuit and another
connected to a monitoring facemask, combined with a leak correction algorithm (LCA) that corrects flow