Palladium-catalyzed C12-selective direct arylation of [1,2-c] quinazolin-6(5H)-ones
A straightforward approach to the synthesis of challenging 12-arylindolo[1,2-c]quinazolin-6(5H)-ones through the palladium-catalyzed direct arylation of N-benzyl and NH-free[1,2-c]quinazolin-6(5H)-ones with aryl bromides and chlorides is described.