Ricerc@Sapienza

Introduction: nuclear medicine plays a crucial role for personalized therapy, mainly in oncology. chemotherapy and radiotherapy present some disadvantages and research is shifting toward nanotechnology with significant improvements in therapy and diagnosis of several cancers. indeed, nanoparticles can be tagged with different radioisotopes for single photon emission computed tomography (SPecT) and positron emission tomography (PeT) imaging and for therapy. This review describes the current state of the art of 64copper-labeled nanoparticles for PeT imaging of cancer.

Large vessel vasculitis (LVV) is defined as a disease mainly affecting the large arteries, with two major variants, Takayasu arteritis (TA) and giant cell arteritis (GCA). GCA often coexists with polymyalgia rheumatica (PMR) in the same patient, since both belong to the same disease spectrum. FDG-PET/CT is a functional imaging technique which is an established tool in oncology, and has also demonstrated a role in the field of inflammatory diseases.

ObjectiveTo investigate whether baseline concentrations of plasma total tau (t-Tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD).MethodsThis was a large-scale study of 276 cognitively intact older adults from the monocentric INSIGHT-preAD (Investigation of Alzheimer's Predictors in Subjective Memory Complainers) cohort.