Inhibition of Polycomb Repressive Complex2 activity reduces trimethylation of H3K27 and affects development in Arabidopsis seedlings
Background: Polycomb repressive complex 2 (PRC2) is an epigenetic transcriptional repression system, whose
catalytic subunit (ENHANCER OF ZESTE HOMOLOG 2, EZH2 in animals) is responsible for trimethylating histone H3
at lysine 27 (H3K27me3). In mammals, gain-of-function mutations as well as overexpression of EZH2 have been
associated with several tumors, therefore making this subunit a suitable target for the development of selective
inhibitors. Indeed, highly specific small-molecule inhibitors of EZH2 have been reported. In plants, mutations in