primary antibody deficiency

Pathophysiology of Natural Killer cells in primary immunodeficiency

Pathophysiology of Natural Killer cells in primary immunodeficiency

We are extending our previous observations on the Impact of vaccination on NK cell compartment. Our study revealed that mRNA based Sars-Cov2 vaccine stably affect NK cell phenotype and functions highlighting the impact of genetic and environmental host-related factors in modulating NK cell susceptibility to post-vaccinal Fc-dependen

PRIN 2022 - L-AIPAD: Lung-Advanced Imaging in Primary Antibody Deficiency

PRIN 2022 - L-AIPAD: Lung-Advanced Imaging in Primary Antibody Deficiency

Le deficienze primarie degli anticorpi (PAD, Primary Antibody Deficiencies) sono un gruppo di malattie caratterizzate da un compromesso dell’immunità umorale, che può colpire soggetti giovani e avere una prognosi sfavorevole. In questo contesto, il coinvolgimento polmonare — che comprende alterazioni acute e croniche sia delle vie aeree che del parenchima — rappresenta una delle principali cause di morbilità e mortalità.

The burden of common variable immunodeficiency disorders: a retrospective analysis of the European Society for Immunodeficiency (ESID) registry data

BACKGROUND: Common variable immunodeficiency disorders (CVID) are a group of rare innate disorders characterized by specific antibody deficiency and increased rates of infections, comorbidities and mortality. The burden of CVID in Europe has not been previously estimated. We performed a retrospective analysis of the European Society for Immunodeficiencies (ESID) registry data on the subset of patients classified by their immunologist as CVID and treated between 2004 and 2014.

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency.

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