Proteomic Analysis of Peripheral Blood Mononuclear Cells after a High-Fat, High-Carbohydrate Meal with Orange Juice
Oxidative stress and inflammation play a role in
the physiopathology of insulin resistance, diabetes and cardio-
vascular disease. A single high-fat, high-carbohydrate (HFHC)
meal induces an increase in inflammatory and oxidative
stress markers in peripheral blood mononuclear cells (PBMC).
Previous studies have shown that orange juice is able to prevent
this response by inhibiting toll like receptors (TLR) expression
and endotoxemia. Our goal was to study the proteome response
in PBMC after the consumption of a HFHC meal consumed