Tumor-derived microvesicles modulate antigen cross-processing via reactive oxygen species-mediated alkalinization of phagosomal compartment in dendritic cells
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and
cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the
induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated,
the in vivo mechanisms underlying efficient antigen cross-processing and presentation
are not fully understood. Several pieces of evidence indicate that antigen transfer to DCs
mediated by microvesicles (MVs) enhances antigen immunogenicity. This mechanism