Ricerc@Sapienza

urs in the elderly population, sometimes in an
advanced stage, when intensive treatments are needed.
Radiotherapy can achieve high response rates. We evaluated
efficacy and tolerability of hypofractionated radiotherapy in
a population of very elderly patients with locally advanced
epithelial skin cancer. Patients and Methods: Two different
hypofractionated schedules were administered (21 patients):
6 Gy in 10 bi-weekly fractions (13 lesions) and 5 Gy in 12
bi-weekly fractions (13 lesions). Median age at treatment was

Ion beam therapy is a rapidly growing technique for tumor radiation therapy. Ions allow for a high dose deposition in the tumor region, while sparing the surrounding healthy tissue. For this reason, the highest possible accuracy in the calculation of dose and its spatial distribution is required in treatment planning. On one hand, commonly used treatment planning software solutions adopt a simplified beam–body interaction model by remapping pre-calculated dose distributions into a 3D water-equivalent representation of the patient morphology.