Ricerc@Sapienza

PURPOSE: The aims of patients' radiological surveillance are to: ascertain relapse; apply second-line therapy; accrue patients in phase 1/2 protocols if second-line therapy is not standardized/curative; and assess/treat iatrogenic effects. To lessen the emotional and socioeconomic burdens for patients and families, we ideally need to establish whether scheduled radiological surveillance gives patients a better outcome than waiting for symptoms and signs to appear.

Background: As for other tumors it is likely that depth of invasion is a prognostic factor for disease recurrence and progression in high grade
pT1 urothelial bladder cancer. To date nor anatomy based neither dimensional subclassification proved reliable correlation with recurrence and
progression, mainly considering the high interobserver variability in pT1 diagnosis, based by the TURB resection technique intrinsic artifact.
Objective: Aim of this study is to assess the feasibility of measuring depth of invasion of urothelial carcinoma in patients undergoing EB-TURB

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Pharmacologic and non-pharmacologic rhythm control strategies impact on AF-related symptoms, while leaving largely unaffected the risk of stroke. Moreover, up to 20% of AF patients are asymptomatic during paroxysmal relapses of arrhythmia, thus underlying the need for early markers to identify at-risk patients and prevent cerebrovascular accidents. Indeed, non-invasive assessment of pre-clinical substrate changes that predispose to AF could provide early identification of at-risk patients and allow for tailored care paths.

This paper considers a random structure on the lattice Z
2 of the following
kind. To each edge e a random variable Xe is assigned, together with a random sign
Y_e ∈ {−1, +1}. For an infinite self-avoiding path on Z
2
starting at the origin consider the
sequence of partial sums along the path. These are computed by summing the Xe’s for
the edges e crossed by the path, with a sign depending on the direction of the crossing.
If the edge is crossed rightward or upward the sign is given by Ye, otherwise by −Ye. We

The role of pathological findings after locoregional treatments as predictors of hepatocellular cancer recurrence after liver transplantation has been poorly addressed. The aim of the study was to identify the role of remnant vital tissue (RVT) of the target lesion in predicting hepatocellular cancer recurrence. Two hundred and seventy-six patients firstly undergoing locoregional treatment and then transplanted between January 2010 and December 2015 in four European Transplant Centres (i.e.

Background: In last years, many attempts were made to recognize chronic rhinosinusitis with nasal polyps (CRSwNP) phenotypes focusing on identifying relevant key pathogenic molecules. Polyps recurrence rate ranges from 4% to 60%, so it's clear that not all clinical and immunologic factors associated with recurrence are known.

BACKGROUND: The treatment of recurrent rhinopharyngitis is mostly symptomatic and based on non-steroidal anti-inflammatory drugs. Mi-HA is a new product based on the dairy strain Lactobacillus helveticus MIMLh5, an inactivated food grade bacterium isolated from Grana Padano cheese, which has immunomodulatory properties and prevents bacterial adhesion to epithelial cells. We retrospectively investigated the effectiveness of Mi-HA to treat recurring rhinopharyngitis.

Sinonasal inverted papilloma (IP) is the most common benign epithelial tumor in the nasal cavity and paranasal sinuses, with a worldwide incidence between 0.6 and 1.5/100 000 persons per year. However, only a few studies have investigated patient-dependent factors related to IP recurrence and persistence. According to available evidence, these factors are still debated, and results are contradictory.

BACKGROUND: Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease. MATERIALS AND METHODS: A literature search was systematically performed. Seven out of 312 articles dated between 2009 and 2018 fulfilled the selection for a total of 5,433 patients.

Background: The 2015 American Thyroid Association (ATA) guidelines proposed a three-category system for estimating the risk of recurrence of differentiated thyroid carcinoma (DTC). This system includes several perioperative features, but not age at diagnosis. However, age has traditionally been recognized as a critical factor in the survival of DTC patients, and the eighth edition of TNM stated that patients older than 55 years were at higher risk of death. In this study, we raised the question of whether age at DTC diagnosis impacts on its risk of recurrence.