Impaired Replication Timing Promotes Tissue-Specific Expression of Common Fragile Sites
Abstract: Common fragile sites (CFSs) are particularly vulnerable regions of the genome that become
visible as breaks, gaps, or constrictions on metaphase chromosomes when cells are under replicative
stress. Impairment in DNA replication, late replication timing, enrichment of A/T nucleotides that
tend to form secondary structures, the paucity of active or inducible replication origins, the generation
of R-loops, and the collision between replication and transcription machineries on particularly long