Ricerc@Sapienza

In this study we sought to evaluate the association between viral bronchiolitis, weather conditions, and air pollution in an urban area in Italy.

We aimed to study respiratory syncytial virus (RSV) genotype distribution, clinical presentation, and disease severity in infants with bronchiolitis from RSV subtypes and new RSV genotypes. Methods: We prospectively enrolled previously healthy term infants less than one year old hospitalized for bronchiolitis in an Italian University hospital over 12 epidemic seasons. In 312 nasopharyngeal washings positive to RSV, we sequenced the viral genotype and analysed it according to patient data. Strain-specific RSV loads were quantified for 300 specimens.

Bronchiolitis is the first lower respiratory tract viral infection manifesting in infants younger than 12 months of age. Our aim was to evaluate clinical and serological differences in infants with bronchiolitis from a single or from multiple viruses. Our secondary aim was to investigate differences in recurrent wheezing episodes after 12-24-36 months of follow-up. We reviewed the clinical records for 486 full-term infants hospitalized for bronchiolitis with at least one virus detected in the nasopharyngeal aspirate.

Respiratory Syncytial Virus (RSV) is the leading cause of bronchiolitis, and the severity may be influenced by the bacterial ecosystem. Our aim was to analyze the nasal microbiota from 48 infants affected by bronchiolitis from RSV virus and 28 infants with bronchiolitis but negative for the virus.

Objective: to study RSV-A genotype ON1 genetic variability and clinical severity in infants hospitalized with bronchiolitis, over six epidemic seasons (2012-2013 to 2017-2018).

Aim: To test the hypothesis that the balance of type-1/type-2 immune response differs between infants hospitalized with respiratory syncytial virus (RSV) bronchiolitis during the peak months and those during the nonpeak months. Methods: We prospectively enrolled 90 unrelated full-term previously healthy infants hospitalized during the first year of life for RSV sole bronchiolitis over 2 epidemics (November 2016 to April 2017 and October 2017 to April 2018). We stratified infants as follows: hospitalized during the peak months (n: 71) and during the nonpeak months (n: 19).