Ricerc@Sapienza

The most prevalent malignancy in the oral cavity is represented by oral
squamous cell carcinoma, an aggressive disease mostly detected in low‐income
communities. This neoplasia is mostly diffused in older men particularly
exposed to risk factors such as tobacco, alcohol, and a diet rich in fatty foods
and poor in vegetables. In oral squamous cell carcinoma, a wide range of
matrix‐cleaving proteinases are involved in extracellular matrix remodeling of
cancer microenvironment. In particular, matrix metalloproteinases (MMPs)

Strongly hydrophilic gold nanoparticles (AuNPs), functionalized with citrate and L-cysteine, were synthetized and used as Resveratrol (RSV) vehicle to improve its bioavailability. Two different conjugation procedures were investigated: the first by adding RSV during AuNPs synthesis (1) and the second by adding RSV after AuNPs synthesis (2). The two different conjugated systems, namely AuNPs@RSV1 and AuNPs@RSV2 respectively, showed good loading efficiency (η%): η1 = 80 ± 5% for AuNPs@RSV1 and η2 = 20 ± 3% for AuNPs@RSV2.

Resveratrol, a natural product with well-known multiple beneficial effects, has been widely used as a bioactive principle for the development of anti-aging topical phytoproducts. These products are usually applied to skin that is often exposed to solar light for a long time, leading to potentially harmful resveratrol derivatives. In this study we investigated the cytotoxicity and genotoxicity of 2,4,6-trihydroxyphenanthrene (THP), derived from trans-resveratrol photochemical isomerization and electrocyclization.

Resveratrol (3,5,40-trihydroxystilbene) is a natural compound that can be found in high concentrations in red wine and in many typical foods found in human diet. Over the past decades, resveratrol has been widely investigated for its potential beneficial effects on human health. At the same time, numerous analytical methods have been developed for the quantitative determination of resveratrol isomers in oenological and food matrices.

Resveratrol (RV) is a polyphenol non-flavonoid compound present in strongly pigmented vegetables and fresh fruits as well as dried nuts such as peanuts. High concentrations of this natural compound were found, in the modern occidental world, in the peel of the berries of the red grape Vitis vinifera, but usage of this natural drug in popular medicine has been documented much earlier. Resveratrol exhibits diverse biological activities such as antitumor, antioxidant, antiviral, and phytoestrogenic.

The aim of the present in vitro study was to compare the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells. We compared the effect of two synthetic mammalian mTOR blockers MC2141 and MC2183 with that of natural/plant-derived mTOR blocker rapamycin and mTOR activator resveratrol on cultured human ovarian granulosa cells. We evaluated the accumulation of markers for the mTOR system (sirtuin 1; SIRT 1), proliferation (PCNA), and apoptosis (caspase 3) along with the expression of the transcription factor p53 by quantitative immunocytochemistry.

Natural antioxidants, such as astaxanthin (AX), resveratrol (RV) and curcumin (CU), are bioactive molecules that show a number of therapeutic effects. However, their applications are remarkably limited by their poor water solubility, physico-chemical instability and low bioavailability.