Risk factor for prostate cancer

VALORE PROGNOSTICO DELLE VARIANTI PATOGENETICHE DI GENI DDR (DNA DAMAGE REPAIR) NEI PAZIENTI CON NUOVA DIAGNOSI DI CARCINOMA PROSTATICO O DI NEOPLASIE DELLO STOMACO, PANCREAS E VIE BILIARI: IMPLICAZIONI DELL’ANALISI EREDO-FAMILIARE

VALORE PROGNOSTICO DELLE VARIANTI PATOGENETICHE DI GENI DDR (DNA DAMAGE REPAIR) NEI PAZIENTI CON NUOVA DIAGNOSI DI CARCINOMA PROSTATICO O DI NEOPLASIE DELLO STOMACO, PANCREAS E VIE BILIARI: IMPLICAZIONI DELL’ANALISI EREDO-FAMILIARE

Prostate cancer has become, in many Western countries, the most frequent cancer in the male population. The etiology of prostate cancer is represented by a complex interaction of genetic and environmental factors.

Low-serum testosterone and high-chromogranin. A are associated with high-grade prostate cancer and higher pathological stages of the disease

INTRODUCTION
CgA and testosterone are two serum markers that may be involved in prostate cancer. The objective of this study was to evaluate the relationship of testosterone and CgA to grades and stages of prostate cancer, particularly whether low-serum testosterone and high-serum CgA are associated with more aggressive grades, and higher pathological stages of the disease.
METHODS:
This perspective study included 121 men (Caucasian only) presenting with -newly-diagnosed, untreated prostate cancer. All the patients underwent radical prostatectomy.
RESULTS:

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