Differential diagnosis in hypogammaglobulinemia
Hypogammaglobulinemias are characterized by low or deficient levels of any of the
immunoglobulins (IgG, IgA, IgM, IgE, and IgG subclasses). This condition repre-
sents a diagnostic challenge for clinicians, due to its association with many patho-
logical entities with different manifestations and outcomes. At the initial evaluation,
several factors should be considered to correctly recognize the possible cause of
hypogammaglobulinemia, including age of onset, sex, number and type immuno-