Ricerc@Sapienza

Objective: To evaluate the efficacy of ospemifene in treating dyspareunia associated with postmenopausal vulvo-vaginal atrophy (VVA). Methods: A structured search was carried out in PubMed-Medlin, Embase, Cochrane Controlled Trials Register databases through to 31 July 2018. The search included the following terms: “Ospemifene” “vulvovaginal atrophy” “dyspareunia” “SERM” and “randomized controlled trial” (RCTs). Four outcomes were selected: vaginal pH; proportions of parabasal and superficial vaginal cells; and perception of the most bothersome symptom (vaginal dryness or dyspareunia).

Wound healing is a physiological process that involves several successive and often overlapping phases that lead to the restoration of the integrity of the skin after an injury, accident or surgery: haemostasis and inflammation, proliferation and remodeling. The interruption or slowing down of these processes can cause abnormal or impaired wound healing. There are now numerous data and clinical studies that highlight the role of estrogens on normal cutaneous homeostasis and wound healing.