PLA short sub-micron fibers reinforcement of 3D bioprinted alginate constructs for cartilage regeneration
In this study, we present an innovative strategy to reinforce 3D printed hydrogel constructs for cartilage tissue engineering by formulating composite bioinks containing alginate and short submicron polylactide (PLA) fibers.Wedemonstrate that Young’s modulus obtained for pristine alginate constructs (6.9?±?1.7 kPa) can be increased threefold (up to 25.1?±?3.8 kPa) with the addition of PLA short fibers.