Signal Transducing | Ricerc@Sapienza

iBright FL1000 Imaging System

Lingua Italiano

The iBright FL1000 Imaging system is a powerful, easy-to-use western blot and gel documentation system. They provides sensitive, streamlined, multimode image capture. This acquisition image instrument connects to the user through a large capacitive touch screen interface and intelligently designed software to provide stunningly easy western blot and gel imaging. Fluorescent detection offers excellent quantitation and multiplex capability. Chemiluminescent detection delivers the ultimate sensitivity for imaging low abundance proteins. These instruments offers both.

AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis

Regulatory T cells (T reg ) are necessary to maintain immunological tolerance and are key players in the control of autoimmune disease susceptibility. Expression of the transcription factor FOXP3 is essential for differentiation of T reg cells and indispensable for their suppressive function. However, there is still a lack of knowledge about the mechanisms underlying its regulation. Here, we demonstrate that pro-autophagy protein AMBRA1 is also a key modulator of T cells, regulating the complex network that leads to human T reg differentiation and maintenance.