Sirtuins as drug targets
The mammalian sirtuins (SIRTs) are evolutionally highly conserved proteins
and belong to class III histone deacetylases (HDACs). Its seven family members
(SIRT1–7) share a NAD+-dependent catalytic protein lysine deacetylase and/or
mono-ADP-ribosylase mechanism and are involved in various biological
processes acting on diverse substrates. SIRTs vary in length and sequence at
their N- and C-termini. This might explain in part their diverse functions and
localizations. To date, their protein lysine deacetylation is the most studied