Ricerc@Sapienza

Background: Migraine is a common headache disorder, with cortical spreading depolarization (CSD) considered as the underlying electrophysiological event. CSD is a slowly propagating wave of neuronal and glial depolarization. Sleep disorders are well known risk factors for migraine chronification, and changes in wake-sleep pattern such as sleep deprivation are common migraine triggers. The underlying mechanisms are unknown.

Study Objectives: To evaluate the effects of total and partial sleep deprivation on reflection
impulsivity and risk-taking in tasks requiring deliberative decision-making processes.
Participants and Methods: Seventy-four healthy young adults were selected to participate
in two independent experiments, each consisting of a crossover design. In Experiment 1, 32
participants were tested after one night of regular sleep (RS), and after one night of total
sleep deprivation (TSD). In Experiment 2, 42 participants were tested following five nights

The ability to experience aesthetics plays a fundamental role in human social interactions, as well as the capacity to feel empathy. Some studies have shown that beauty perception shares part of the neural network underlying emotional and empathic abilities, which are also known to affect sleep quality and duration. In this study, we evaluated for the first time the effects of sleep on the relation between aesthetic perception and empathic abilities in healthy subjects using a mediation analysis approach. One-hundred and twenty-six subjects participated in this study.

Sleep deprivation consistently increases food intake. This study aimed to evaluate the effect of partial sleep deprivation on food intake in individuals reporting binge eating, controlling for self-reported depressive emotional eating. Fourteen young adults reporting binge eating symptoms and 14 controls denying any eating disorders symptoms were offered a large and varied breakfast after a night of habitual sleep (HN) and after a night of partial sleep deprivation (DN). Food intake was unobtrusively measured while daily food intake was measured via a food diary.

Background: Experimental studies consistently demonstrate that acute sleep depri- vation increases food consumption. Moreover, epidemiological studies and meta- analyses show that children with short sleep have twice the probability of suffering from obesity than normal sleepers. Similar results are reported in adolescents, while in adults' results are heterogeneous. Habitual sleep patterns, however, have not been taken into account to date, yet they may explain this heterogeneity.

Introduction: Acute partial sleep deprivation has been shown to consis- tently increase food intake. This study aimed to evaluate the effect of sleep deprivation on food intake in individuals reporting or not binge eating symptoms, controlling for self-reported emotional eating (EE).

Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers.