Ricerc@Sapienza

Mushrooms represent a formidable source of bioactive compounds. Some of these may be considered as biological response modifiers; these include compounds with a specific biological function: antibiotics (e.g. plectasin), immune system stimulator (e,g, lentinan), antitumor agents (e.g. krestin, PSK) and hypolipidemic agents (e.g. lovastatin) inter alia. In this study, we focused on the Chinese medicinal mushroom "yun zhi", Trametes versicolor, traditionally used for (cit.) "replenish essence and qi (vital energy)".

Spectrometric and analytical techniques in general collect multivariate signals from chemical or biological materials by means of a specific measurement instrumentation, usually in order to characterize or classify them through the estimation of one of several compounds of interest. However, measurement conditions might induce various additive (baseline) or multiplicative effects on the collected signals, which may jeopardize the accuracy and generalizability of estimation models.

The structural characterization of the lipopolysaccharide (LPS) from extremophiles has
important implications in several biomedical and therapeutic applications. The polyextremophile
Gram-negative bacterium Halobacteroides lacunaris TB21, isolated from one of the most extreme
habitats on our planet, the deep-sea hypersaline anoxic basin Thetis, represents a fascinating
microorganism to investigate in terms of its LPS component. Here we report the elucidation of